缺血再灌注对鼠脑血管内皮生长因子表达的影响Expression of Vascular Endothelial Growth Factor in Rat Brains Following Transient Global Ischemia
程敬君,匡培根
摘要(Abstract)：
目的 了解血管内皮生长因子 (VEGF)在一过性全脑缺血再灌注鼠脑表达的动态变化。方法 采用Pulisnelli改良法四血管堵塞全脑缺血再灌注模型 ,用免疫组织化学方法观察了全缺血 15min再灌注 2h～ 14d时 ,VEGF表达的动态变化。结果 全脑缺血 15min再灌注 6hVEGF即可在大脑皮层、纹状体及丘脑等区域的血管内皮细胞表达 ,1d达高峰 ,一直持续到缺血后再灌注 3d。结论 脑缺血后再灌注可上调VEGF在大脑皮质、纹状体及丘脑等区域内皮细胞的表达 ,VEGF可能通过促进血管内皮细胞生长对缺血性神经元损伤起一定的作用。
关键词(KeyWords)： 脑缺血再灌注;血管内皮生长因子;免疫组织化学
基金项目(Foundation): 军事医学科学院创新基金!资助项目 (No .2 0 12 0 4)
作者(Author): 程敬君,匡培根
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