张歆;黄南渠;巴智胜;罗勇;

• 1:遵义医科大学第三附属医院神经内科
• 2:遵义医科大学第三附属医院药物临床试验机构办公室

摘要(Abstract)：

阿尔茨海默病(Alzheimer disease,AD)是老年痴呆中最常见的一种类型,是以进行性认知功能减退及行为改变为特征的中枢神经系统退行性疾病。随世界人口老龄化进程的发展,AD的发病率逐渐升高,但目前其发病机制尚未能明确,亦无针对该病有效的预防和治疗方案。近年来部分研究发现,凋亡通路的激活是AD的早期事件,TDP-43可能在凋亡通路中发挥作用,其突变可能促发细胞凋亡的连锁反应,最终导致AD的发生,提示TDP-43或许是AD的潜在治疗靶点。本文就TDP-43与AD细胞凋亡相关性的研究进展做一综述。

关键词(KeyWords)： 细胞凋亡;TDP-43;凋亡相关蛋白;阿尔茨海默病

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81860710,81650030);; 遵义市科技局计划课题(2017-29)

作者(Author): 张歆;黄南渠;巴智胜;罗勇;

Email:

DOI:

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