拉莫三嗪添加或单药治疗部分发作性癫痫的有效性和耐受性研究The Efficacy and Tolerability of Lamotrigine Adj unctive/Monotherapy among Patients with Partial Seizures
宋春杰;陈惠玲;王小勇;张克忠;王辉;万琪;
摘要(Abstract)：
目的探讨拉莫三嗪(LTG)治疗对多种抗癫痫药物疗效不佳的部分发作性癫痫患者的有效性和耐受性。方法入组患者为多中心来源,主要终点指标为使用利物浦不良体验量表(LAEP)测试患者对药物的耐受性,次要指标为癫痫患者生活质量表(QOLIE)-31,同时记录患者的临床发作控制率。结果入组患者114例,105例患者完成了LTG加量期治疗。与基线期比较,LTG加量期结束时患者LAEP评分改善2.6分(P<0.05),QOLIE-31总体评分提高8.49分(P<0.01)。试验结束时有26例患者实现了LTG单药治疗,65例临床发作控制率达到50%以上,与基线期比较,LAEP评分改善5.1分(P<0.01),QOLIE-31总体评分提高12.72分(P<0.01)。结论对多种抗癫痫药物治疗不佳的部分发作性癫痫患者合用LTG可有效改善患者生活质量,控制发作和提高患者对药物的耐受性。
关键词(KeyWords)： 部分性发作;抗癫痫药物;拉莫三嗪;单药治疗;添加治疗
基金项目(Foundation):
作者(Author): 宋春杰;陈惠玲;王小勇;张克忠;王辉;万琪;
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参考文献(References)：
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