袁静静;李泽宇;殷旭华;

• 1:内蒙古医科大学第一附属医院神经内科

摘要(Abstract)：

视神经脊髓炎(NMO)是一种主要累及视神经和脊髓的原发性中枢神经系统炎性脱髓鞘疾病,既往被认为是多发性硬化(MS)的亚型,但近年发现NMO在免疫机制、临床和影像学表现、病理改变及治疗等方面均与MS不同。NMO-IgG,即中枢神经系统水通道蛋白4(AQP4)抗体是NMO较为特异的一项免疫标志物,它的发现将NMO与MS独立开来。本文对NMO的免疫机制、病理、临床和影像学及治疗等方面进行综述。

关键词(KeyWords)： 视神经脊髓炎;临床表现;诊断;治疗

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 袁静静;李泽宇;殷旭华;

Email:

DOI:

参考文献(References)：

• [1]Devic E.Myelite subaigue compliquee de nevrite optique[J].Bull Med(Paris),1894,8:1033-1034.
• [2]Lennon VA,Wingerchuk DM,Kryzer TJ,et al.A serurn au-toanti bodymarker of neuromyelitis optica:distinetion from multiple selerosis[J].Laneet,2004,364(9451):2106-2112.
• [3]O’Riord JI,Gallagher HL,Thnompson AJ,et a1.Clinical,CSF and MRI findings in Devic’s neuromyelitis optica[J].J Neurol Neumsurg Psychiatry,1996,60(40):382-387.
• [4]Takahashi T,Fujihara K,Nakashima I,et al.Antiaquaporin-4 antibody is involved in the pathogenesis of NMO:a study on antibody titre[J].Brain,2007,130(5):1235-1243.
• [5]Weinshenker BG,Wingerchuk DM,Vukusic S,et al.Neuro-myelitis optica IgG predicts relapse after longitudinally exten-sive transverse myelitis[J].Ann Neurol,2006,59(3):566-569.
• [6]Matiello M,Lennon VA,Jacob A,et al.NMO-IgG predicts the outcome of recurrent optic neuritis[J].Neurology,2008,70(23):2197-2200.
• [7]Kim W,Kim SH,Kim HJ,et al.New insinghts into neuromy-elitis optica[J].J Clin Neurol,2011,7(3):115-127.
• [8]Vincent T,Saikali P,Cayrol R,et al.Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment[J].J Immunol,2008,181(8):5730-5737.
• [9]Saadoun S,Waters P,Bell BA,et al.Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human comple-ment produces neuromyelitis optica lesions in mice[J].Brain,2010,133(2):349-361.
• [10]Chihara N,Aranami T,Sato W,et al.Interleukin6signaling promotes anti-aquaporin4autoantibody production from plas-mablasts in neuromyelitis optica[J].Proc Natl Acad Sci USA,2011,108(9):3701-3706.
• [11]Wingerchuk DM.Neuromyelitis optica[J].Int MS J,2006,13(2):42-50.
• [12]Mandler RN.Neuromyelitis optica Devic’s syndrome,update[J].Autoimmu Rev,2006,5(8):537-543.
• [13]Misu T,Fujihara K,Nakashima I,et al.Intractable hiccup and nausea with periaqueductal lesions in neuromyelitis optica[J].Neurology2005,65(9):1479-1482.
• [14]Pittock SJ,Weinshenker BG,Lucchinetti CF,et al.Neuromy-elitis optica brain lesions localized at sites of high aquaporin4 expression[J].Arch Neurol,2006,63(7):964-968.
• [15]Bergamaschi R,Tonietti S,Franciotta D,et al.Oligoclonal bands in Devic’s neuromyelitis optica and multiple sclerosis:difference in repeated cerehrospinal fluid examinations[J].Mult Scler,2004,10(1):2-4.
• [16]Wingerchuk DM,Lennon VA,Pittock SJ,et a1.Rivised diag-nostic criteria for neummyelitis optica[J].Neurology,2006,66(10):1485-1489.
• [17]Sato D,Callegaro D,Lana-Peixoto MA,et al.Treatment of neuromyelitis optica:an evidence based review[J].Arq Neu-ropsiquiatr,2012,70(1):59-66.
• [18]Carroll WM,Fujihara K.Neuromyelitis optica[J].Curr Treat Options Neurol,2010,12(3):244-255.
• [19]Sellner J,Boggild M,Clanet M,et al.EFNS guidelines on di-agnosis and management of neuromyelitis optica[J].Eur J Neurol,2010,17(8):1019-1032.
• [20]Shimizu J,Hatanaka Y,Hasegawa M,et al.IFNβ-1bmay se-verely exacerbate Japanese optic-spinal MS in neuromyelitis optica spectrum[J].Neurology,2010,75(16):1423-1427.
• [21]Xu Y,Zhang Y,Ye J,et al.Successful treatment of a woman with relapsing neuromyelitis optica by interferon beta success-ful treatment of a woman with relapsing neuromyelitis optica by interferon beta[J].Neurol Sci,2012,33(4):911-913.