Toll样受体4在乙醇所致的小胶质细胞激活中的作用
张丽丽;段淑荣;赵敬堃;张黎明;
摘要(Abstract)：
滥用乙醇可以导致脑损害以及神经系统退行性变,但是其对脑损害的神经性炎性反应方面机制的研究还不明确。近年相关研究结果显示小胶质细胞作为中枢神经系统的主要炎性细胞,在乙醇所致的神经性炎性反应中作用非常重要。Toll样受体4(TLR4)是固有免疫系统中的一个重要模式识别受体,在脑损害和神经系统退行性变中起到重要作用。乙醇通过TLR4信号通路激活小胶质细胞,诱导炎性反应介质释放和细胞死亡而导致脑损害,抑制TLR4信号通路可能对减轻乙醇所致的神经性炎性损害具有重要意义。本文对Toll样受体4在乙醇所致的小胶质细胞激活中的作用做一综述。
关键词(KeyWords)： 乙醇;炎症;小胶质细胞;Toll样受体4
基金项目(Foundation):
作者(Author): 张丽丽;段淑荣;赵敬堃;张黎明;
Email:
DOI:
参考文献(References)：
- [1]Blanco AM,Guerri C.Ethanol intake enhances inflammatorymediators in brain:role of glia cells and TLR4/IL-1R1recep-tors[J].Front Biosci,2007,12:2616-2630.
- [2]Qin L,He J,Hanes RN,et al.Increased systermic and braincytokine production and neuroinflammation by endotoxin fol-lowing ethanol treatment[J].J Neuroinflammation,2008,5:10.
- [3]He J,Crew ET.Increased MCP-1and microglia in various re-gions of the human alcoholic brain[J].Exp Neurol,2008,210:349-358.
- [4]Wojtera M,Sikorska B,Sobow T,et al.Microglial cells in neu-rodegenerative disorders[J].Folia Neuropathol,2005,43:311-321.
- [5]刘桂东,肖勤,陈生弟.小胶质细胞在肌萎缩侧索硬化症研究中的作用[J].中国神经免疫学和神经病学杂志,2008,15(6):461-462.
- [6]Migule-Hidalgo JJ,Wei J,Andrew M,et al.Glia pathology inthe prefrontal cortex in alcohol dependence with and withoutdepressive symptoms[J].Biol Pyschiatry,2002,52:1121-1133.
- [7]Fernandez-Lizarbe S,Pascual M,Guerri C.Critical role ofTLR4response in the activation of microglia induced by etha-nol[J].J Immunol,2009,183:4733-4744.
- [8]Boyadjievia NI,Sarkar DK.Role of microglia in ethanol’s ap-optotic action on hypothalamic neuronal cells in primary cul-tures[J].Alcohol Clin Exp Res,2010,34(11):1835-1842.
- [9]Potula R,Haorah J,Knipe B,et al.Alcohol abuse enhancesneuroinflammation and impairs immune responses in an animalmodel of human immunodeficiency virus-1encephalitis[J].Am J Pathol,2006,168:1335-1344.
- [10]Okun E,Griffioen KJ,Lathia JD,et al.Toll-like receptors inneurodegeneration[J].Brain Res Rev,2009,59:278-292.
- [11]Bsibsi M,Ravid R,Gveric D,et al.Broad expression of Toll-like receptors in the human central nervous system[J].JNeuropathol Exp Neurol,2002,61(11):1013-1021.
- [12]Yang Q W,Xiang J,Zhou Y,et al.Targeting HMGB1/TLR4signaling as a novel approach to treatment of cerebralischemia[J].Front Biosci(Schol Ed),2010,2:1081-1091.
- [13]Alfonso-Loeches S,Pascual-Lucas M,Blanco M,et al.Pivot-al role of TLR4receptors in alcohol-induced neuroinflamma-tion and brain damage[J].J Neurosci,2010,30(24):8285-8295.