青中年轻度认知损害的危险因素分析Research on Risk Factors of the Mild Cognitive Impairment in the Young and Middle Age Patients
高金颖;樊东升;沈扬;古雅兰;杨志杰;
摘要(Abstract)：
目的探讨轻度认知损害(MCI)的相关危险因素。方法对2003-10-2004-10北京大学医学部第三医院289例就诊患者进行神经心理测定,对存在睡眠呼吸暂停的患者进行多导睡眠仪(PSG)检查,确诊阻塞性睡眠呼吸暂停综合征(OSAS)患者171例,MCI患者31例;通过logistic回归分析法分析MCI患者患病的危险因素。结果单因素分析显示,文化程度、吸烟史、饮酒史、腔隙性脑梗死、TIA发作、OSAS史与MCI发生有关。多因素分析显示,文化程度(OR:0.270)、短暂性脑缺血发作(TIA)史(OR:3.462)、吸烟史(OR:2.963)、重度OSAS(OR:1.346)是青中年认知功能损害的主要影响因素。结论文化程度、吸烟史、TIA史、OSAS是青中年认知功能损害的可能影响因素。
关键词(KeyWords)： 中青年;轻度认知损害;危险因素
基金项目(Foundation):
作者(Author): 高金颖;樊东升;沈扬;古雅兰;杨志杰;
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参考文献(References)：
- [1]Peterson RC,Stevens JC,Ganguli M,et al.Early detection of dementia:Mild cognitive impairment(anevidence-based review)[J].Neurology,2001,56:1133-1142.
- [2]Kivipelto M,Helkala EL,Hanninen T,et al.Mildlife vascular risk factors and late-life mild cognitive impairment:Apopulation-based study[J].Neurology,2001,56(12):1683-1689.
- [3]DeCarli C,Miller BL,Swan GE,et al.Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart,Lung,and Blood Institute Twins Study[J].Arch Neurlo,2001,58(4):643-647.
- [4]Ritchie K,Touchon J.Mild cognitive impairment:con-ceptual basis and current nosological status[J].Lan-cet,2000,355(9199):225-228.
- [5]Ritchie K,Artero S,Touchon J.Classification criteria for mild cognitive impairment:a population-based vali-dation study[J].Neurology,2001,56(1):37-42.
- [6]Graham J E,Rockwood K,Beattle BL,et al.Preva-lence and severity of cognitive impairment with and without dementia in an elderly population[J].Lancet,1997,349:1793-1796.
- [7]孟琛,汤哲.社区老年人认知功能变化及其预后的五年前瞻性研究[J].中华神经科杂志,2000,33(3):138-140.
- [8]彭海英,郑志学,朱汉民,等.4510名老年人认知功能调查结果的分析[J].中国老年学杂志,1999,19(2):65.
- [9]Meyer JS,Rauch G,Ranch RA,et al.Risk factors for cerebral hypoperfusion,mild cognitive impairment,and dementia[J].Neurobiol Aging,2000,21(2):161-169.
- [10]Klein JB,Gozal D,Pierce WM,et al.Proteomic identification of a novel protein regulated in CA1and CA3hippocampal regions during intermittent hypoxia[J].Respir Physiol Neurobiol,2003,136:91-103.
- [11]Jordan W,HagedohmJ,Wiltfang J,et al.Biochemical markers of cerebrovascular injury in sleep apnea syn-drome[J].Eur Respir J,2002,20(1):158-164.