牛会丛;张星虎;

• 1:首都医科大学附属北京天坛医院神经内科

摘要(Abstract)：

视神经脊髓炎(neuromyelitis optica,NMO)自从1894年被Devic首次描述以来,NMO和多发性硬化(multiple sclerosis,MS)之间的关系一直备受争议。最近来自临床、影像、病理、流行病学、免疫学的研究均提示NMO和MS是两种不同的疾病。2004年Lennon等在NMO患者血清中发现了一种特异性抗体,并将其命名为NMO-IgG,使人们对NMO的病理生理过程有了更加深入的了解,后证实其是针对中枢神经系统水通道蛋白4(aquaporin-4,AQP4)的抗体。由于发病机制的不同,MS和NMO在治疗上存在明显差异。现就NMO的免疫病理机制及治疗进行综述。

关键词(KeyWords)： 视神经脊髓炎;发病机制;治疗

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 牛会丛;张星虎;

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参考文献(References)：

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