抗γ-氨基丁酸B受体脑炎一例
姚本海;刘海军;周庆;詹剑;余昌胤;徐忠祥;
摘要(Abstract)：
<正>1病例报告患者男,40岁。因"头晕头痛伴发作性意识障碍及抽搐2周,再发1d"于2017-06-28入院。2周前无明显诱因出现头晕、头痛,第2天出现意识障碍,呼之不应,牙关紧闭,舌咬伤,四肢强直-阵挛,大小便失禁,持续2min,次数不详。就诊当地医院ICU考虑"病毒性脑炎、继发性癫痫"。患者抽搐频繁发作、血氧饱和度不能维持,行气管插管呼吸机辅助治疗,治疗3d抽搐得到控制,患者意识转清。转入普通病房5d后病情稳定出院。1d前出现胡言乱语,烦躁不安,抽搐发作10余次,性质同前,伴发热
关键词(KeyWords)： 受体,GABA;脑炎;癫痫;小细胞肺癌
基金项目(Foundation):
作者(Author): 姚本海;刘海军;周庆;詹剑;余昌胤;徐忠祥;
Email:
DOI:
参考文献(References)：
- [1] Lancaster E,Martinez-Hernandez E.Encephalitis and antibodies to synaptic and neuronal cell surface proteins[J].Neurology,2011,77(2):179-189.
- [2] Wu XH,Song JJ,Faull RLM,et al.GABAA and GABAB receptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus[J].J Comp Neurol,2018,526(5):803-823.
- [3] Sheilabi MA,Battacharyya D,Caetano L,et al.Quantitative expression and localization of GABAB receptor protein subunits in hippocampi from patients with refractory temporal lobe epilepsy[J].Neuropharmacology,2018,136(PtA):117-128.
- [4] Chen X,Liu F,Li JM,et al.Encephalitis with antibodies against the GABAB receptor:seizures as the most common presentation at admission[J].Neurol Res,2017,39(11):973-980.
- [5] Gozzard P,Woodhall M,Chapman C,et al.Paraneoplastic neurologic disorders in small cell lung carcinoma:a prospective study[J].Neurology,2015,85(3):235-239.
- [6] Kim TJ,Lee ST,Shin JW,et al.Clinical manifestations and outcomes of the treatment of patients with GABABencephalitis[J].J Neuroimmunol,2014,270(1-2):45-50.
- [7] Guan HZ,Ren HT,Yang XZ,et al.Limbic encephalitis associated with antio-γ-aminobutyric acid B receptor antibodies:A case series from China[J].China Med J,2015,128(22):3023-3028.
- [8] Lancaster E,Lai M,Peng X,et al.Antibodies to the GABA(B) receptor in limbic encephalitis with seizures:case series and characterisation of the antigen[J].Lancet Neurology,2010,9(1):67-76.
- [9] Titulaer MJ,Soffietti R,Dalmau J,et al.Screening for tumours in paraneoplastic syndromes:report of an EFNS task force[J].Eur J Neurology,2011,18(1):19-e3.