α-synuclein与帕金森病(综述)
范国华,刘振国,陈生弟
摘要(Abstract)：
α-synuclein是一种位于突触前末梢的蛋白 ,NACP是 α-synuclein的人类同系物。α-synuclein基因的两种错义突变与家族性帕金森病 (FPD)密切相关。目前大量研究发现在 PD的路易小体中有 NACP的免疫阳性反应 ,推测 α-synuclein可能参与路易小体的形成及神经变性过程。本文就 α-synuclein基因、α-synuclein蛋白的聚集及其在 PD发病机制中作用等方面的研究做一综述。
关键词(KeyWords)： α-synuclein/NACP;帕金森病;路易小体
基金项目(Foundation):
作者(Author): 范国华,刘振国,陈生弟
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