周永红;王新陆;张玉杰;胡怀强;

• 1:青岛大学医学院中医教研室
• 2:山东中医药大学临床学院
• 3:青岛大学医学院中医教研室
• 4:山东中医药大学临床学院 山东青岛266021

摘要(Abstract)：

目的观察中药复方复健片对大脑中动脉闭塞模型大鼠脑内多唾液酸-神经细胞黏附分子(PSA-NCAM)的影响,探讨其促进神经发生的作用机制。方法60只Wistar大鼠随机分为药物组、模型组、假手术组,每组20只。用Tamura等方法制备大脑中动脉闭塞大鼠模型,于造模成功后6 h药物组按体重9 g/kg经灌胃给予复健片水溶液,余两组分别经灌胃给予同等量生理盐水(NS),1次/d,共7 d。用免疫组化法观察大脑中动脉闭塞模型大鼠脑内PSA-NCAM的表达,并对切片进行图像分析,测定染色平均灰度。结果56只大鼠纳入结果分析。给药1周后大鼠脑内PSA-NCAM染色平均灰度药物组为100.10±2.28,模型组为128.65±1.12,假手术组为140.20±8.68。药物组、模型组与假手术组组间比较差异有统计学意义(P<0.01),药物组与模型组比较差异有统计学意义(P<0.01)。结论复健片可显著增强大脑中动脉闭塞大鼠脑内PSA-NCAM的表达,从而促进缺血性脑卒中神经的发生。

关键词(KeyWords)： 中药;脑缺血;多唾液酸-神经细胞黏附分子

Abstract:

Keywords:

基金项目(Foundation): 山东省科技发展计划基金资助项目(2006GG3202005)

作者(Author): 周永红;王新陆;张玉杰;胡怀强;

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DOI:

参考文献(References)：

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