牛宝丰;周卫东;刘长春;曾庆玉;尹晓明;张文静;

• 1:煤炭总医院神经内科
• 2:煤炭总医院影像科
• 3:煤炭总医院病案统计室

摘要(Abstract)：

目的探讨椎-基底动脉系统短暂性脑缺血发作(VB-TIA)患者脑白质变性(leukoaraiosis,LA)的危险因素。方法回顾性连续选取313例住院行头颅MRI检查的VB-TIA患者,以所收集的患者性别、年龄、心电图RV5+SV2电压值(mV)、是否有颈动脉斑块、C-反应蛋白(CRP)、胆固醇(TC)、高密度脂蛋白(HDL)、三酰甘油(TG)、低密度脂蛋白(LDL)、尿酸(UA)、同型半胱氨酸(Hcy)、糖化血红蛋白(HbA1c)、叶酸(FA)、维生素B12水平(VB12)等临床资料为自变量,以是否并发LA为因变量,先对各自变量分别进行单因素Logistic回归分析,再对单因素分析有统计学意义自变量进行多因素Logistic回归分析。结果并发LA的VB-TIA患者与未并发LA的VB-TIA患者间年龄、心电图RV5+SV2电压值、CRP、HDL、Hcy、FA和颈动脉斑块发生率比较差异有统计学意义(P<0.1);将上述单因素Logistic回归分析有统计学意义的自变量纳入多因素Logistic回归分析进行校正,结果显示年龄增长(P=0.000,OR=1.116,95%CI:1.081~1.153)、颈动脉斑块(P=0.000,OR=4.881,95%CI:2.510~9.493)和低HDL水平(P=0.017,OR=3.676,95%CI:1.267~10.638)为VB-TIA患者并发LA的独立危险因素。结论年龄增长、颈动脉斑块及低HDL水平可能为VB-TIA患者LA发生的独立危险因素。

关键词(KeyWords)： 脑缺血发作,短暂性;椎基底动脉系统供血不足;脑白质疏松症;危险因素

Abstract:

Keywords:

基金项目(Foundation): 首都卫生发展科研专项项目(2011-6011-01)

作者(Author): 牛宝丰;周卫东;刘长春;曾庆玉;尹晓明;张文静;

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DOI:

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