主观认知障碍相关概念的研究进展
刘江红;董静;邢怡;
摘要(Abstract):
随着对阿尔茨海默病研究的深入,人们发现有些药物虽然理论上能够减缓或减轻患者的病理改变,但是在临床实践中却并不能改善或者逆转疾病的进程,原因可能是由于药物主要针对的是阿尔茨海默病的早期事件或者是临床前事件,所以,有必要在阿尔茨海默病的临床前期尚未出现症状的时候进行早期诊断并干预,甚至需要在轻度认知障碍的前期即做出诊断。正因如此,主观认知障碍引起了研究者们的重视。本文就主观认知障碍概念的形成和发展进行综述。
关键词(KeyWords): 认知障碍;阿尔茨海默病;主观
基金项目(Foundation): 国家自然科学基金资助项目(81301208);; 教育部博士点基金资助项目(20131107120002);; 首都医科大学临床-基础合作项目(13JL70)
作者(Author): 刘江红;董静;邢怡;
Email:
DOI:
参考文献(References):
- [1]Reisberg B,Ferris SH,de Leon MJ,et al.The Global Deterioration Scale for assessment of primary degenerative dementia[J].Am J Psychiatry,1982,139(9):1136-1139.
- [2]Jonker C,Geerlings MI,Schmand B.Are memory complaints predictive for dementia?A review of clinical and populationbased studies[J].Int J Geriatr Psychiatry,2000,15(11):983-991.
- [3]Iliffe S,Pealing L.Subjective memory problems[J].BMJ,2010,340:c1425.
- [4]Mitchell AJ.The clinical significance of subjective memory complaints in the diagnosis of mild cognitive impairment and dementia:a meta-analysis[J].Int J Geriatr Psychiatry,2008,23(11):1191-1202.
- [5]Petersen RC,Caracciolo B,Brayne C,et al.Mild cognitive impairment:a concept in evolution[J].J Intern Med,2014,275(3):214-228.
- [6]Wang L,van Belle G,Crane PK,et al.Subjective memory deterioration and future dementia in people aged 65and older[J].J Am Geriatr Soc,2004,52(12):2045-2051.
- [7]Reisberg B,Shulman MB,Torossian C,et al.Outcome over seven years of healthy adults with and without subjective cognitive impairment[J].Alzheimers Dement,2010,6(1):11-24.
- [8]Reisberg B.Dementia:a systematic approach to identifying reversible causes[J].Geriatrics,1986,41(4):30-46.
- [9]Reisberg B,Gauthier S.Current evidence for subjective cognitive impairment(SCI)as the pre-mild cognitive impairment(MCI)stage of subsequently manifest Alzheimer’s disease[J].Int Psychogeriatr,2008,20(1):1-16.
- [10]Prichep LS,John ER,Ferris SH,et al.Prediction of longitudinal cognitive decline in normal elderly with subjective complaints using electrophysiological imaging[J].Neurobiol Aging,2006,27(3):471-481.
- [11]Wang PN,Wang SJ,Fuh JL,et al.Subjective memory complaint in relation to cognitive performance and depression:a longitudinal study of a rural Chinese population[J].J Am Geriatr Soc,2000,48(3):295-299.
- [12]St John P,Montgomery P.Are cognitively intact seniors with subjective memory loss more likely to develop dementia?[J].Int J Geriatr Psychiatry,2002,17(9):814-820.
- [13]Abdulrab K,Heun R.Subjective memory impairment.A review of its definitions indicates the need for a comprehensive set of standardised and validated criteria[J].Eur Psychiatry,2008,23(5):321-330.
- [14]Jessen F,Amariglio RE,van Boxtel M,et al.A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer’s disease[J].Alzheimers Dement,2014,10(6):844-852.
- [15]Wang Y,Risacher SL,West JD,et al.Altered default mode network connectivity in older adults with cognitive complaints and amnestic mild cognitive impairment[J].J Alzheimers Dis,2013,35(4):751-760.
- [16]Scheef L,Spottke A,Daerr M,et al.Glucose metabolism,gray matter structure,and memory decline in subjective memory impairment[J].Neurology,2012,79(13):1332-1339.
- [17]Perrotin A,Mormino EC,Madison CM,et al.Subjective cognition and amyloid deposition imaging:a Pittsburgh Compound B positron emission tomography study in normal elderly individuals[J].Arch Neurol,2012,69(2):223-229.
- [18]Rami L,Fortea J,Bosch B,et al.Cerebrospinal fluid biomarkers and memory present distinct associations along the continuum from healthy subjects to AD patients[J].J Alzheimers Dis,2011,23(2):319-326.
- [19]Peter J,Scheef L,Abdulkadir A,et al.Gray matter atrophy pattern in elderly with subjective memory impairment[J].Alzheimers Dement,2014,10(1):99-108.
- [20]van Harten AC,Visser PJ,Pijnenburg YA,et al.Cerebrospinal fluid Abeta42is the best predictor of clinical progression in patients with subjective complaints[J].Alzheimers Dement,2013,9(5):481-487.
- [21]Dubois B,Feldman HH,Jacova C,et al.Research criteria for the diagnosis of Alzheimer’s disease:revising the NINCDS-ADRDA criteria[J].Lancet Neurol,2007,6(8):734-746.
- [22]Dubois B,Feldman HH,Jacova C,et al.Advancing research diagnostic criteria for Alzheimer’s disease:the IWG-2criteria[J].Lancet Neurol,2014,13(6):614-629.