侯晓华;赵姝;林志国;张黎明;

• 1:哈尔滨医科大学第一临床医学院神经内科

摘要(Abstract)：

目的检测脑源性神经营养因子(BDNF)及其受体酪氨酸激酶B受体(TrkB)在难治性颞叶癫痫(TLE)患者颞叶和/或海马中的含量,探讨其在癫痫发病机制中的作用。方法选取经手术治疗的82例难治性TLE患者术中切除的海马或颞叶脑组织,用免疫组化方法对BDNF及其受体TrkB含量进行检测,并与11例对照进行比较。结果在难治性TLE患者中,BDNF在颞叶和海马中含量明显增加(分别P<0.05,P<0.01),且海马中含量明显高于颞叶(P<0.01);TrkB在颞叶和海马中含量显著增加(P<0.01),且海马中含量高于颞叶(P<0.05)。结论难治性TLE患者海马和颞叶中BDNF和TrkB含量增高,可能在癫痫发生、发展中起重要作用。

关键词(KeyWords)： 脑源性神经营养因子;酪氨酸激酶B受体;颞叶癫痫

Abstract:

Keywords:

基金项目(Foundation): 黑龙江省科委公关基金资助项目(GB06C40307)

作者(Author): 侯晓华;赵姝;林志国;张黎明;

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参考文献(References)：

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