常琦;吴元波;任明山;吴元洁;叶山东;杨光伟;

• 1:安徽医科大学附属省立医院神经内科
• 2:安徽中医药大学中医基础教研室
• 3:安徽医科大学附属省立医院内分泌科

摘要(Abstract)：

目的探讨2型糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)相关危险因素。方法回顾性分析710例2型糖尿病住院患者的病史资料,采用震动感觉阈值(vibration perception threshold,VPT)评估DPN病情严重程度,根据VPT评分将DPN严重程度分为轻、中、重3组,分别与无DPN组比较临床特征、血生化及常规指标等的差异;采用Ordinal回归分析探讨DPN发生的危险因素。结果本组资料DPN的总发生率为57.2%,其中轻、中、重度3组患者DPN的发生率分别为22.4%、21.0%、13.8%。病程、体重指数(BMI)、糖化血红蛋白(HbAlc)、血清丙氨酸氨基转移酶(ALT)、天氡氨酸氨基转移酶(AST)、红细胞体积分布宽度(RDW-CV)、平均红细胞血红蛋白浓度(MCHC)、糖尿病视网膜病变(DR)发生率、外周动脉疾病(PAD)发生率在轻、中、重度DPN组和无DPN组间比较差异有统计学意义(均P<0.05)。Ordinal回归分析显示病程、HbAlc、BMI、AST、RDW-CV、DR、PAD为DPN发生的影响因素(均P<0.05)。结论病程、HbAlc、BMI、AST、RDW-CV、并发PAD及并发DR可能是DPN发生的危险因素。

关键词(KeyWords)： 糖尿病,2型;糖尿病并发症;震动感觉阈值;危险因素

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81102626H2716)

作者(Author): 常琦;吴元波;任明山;吴元洁;叶山东;杨光伟;

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DOI:

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